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Elucidating parasite and host-cell factors enabling Babesia infection in sickle red cells under hypoxic/hyperoxic conditions

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Key Points • A novel image flow cytometric machine learning tool was developed that robustly identified sickled cells and their constituent hemoglobin.• Multiple mechanisms of resistance are offered by sickle/sickle… Click to show full abstract

Key Points • A novel image flow cytometric machine learning tool was developed that robustly identified sickled cells and their constituent hemoglobin.• Multiple mechanisms of resistance are offered by sickle/sickle trait red blood cells against Babesia, especially in low-oxygen environments.

Keywords: parasite host; factors enabling; host cell; elucidating parasite; enabling babesia; cell factors

Journal Title: Blood Advances
Year Published: 2022

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