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Kindlin-3 deficiency leads to impaired erythropoiesis and erythrocyte cytoskeleton

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Key Points • Kindlin-3 promotes EBI formation and regulates erythropoiesis.• By linking to F-actin and spectrin, kindlin-3 maintains the erythrocyte cytoskeleton to support normal erythrocyte shape and deformability. Click to show full abstract

Key Points • Kindlin-3 promotes EBI formation and regulates erythropoiesis.• By linking to F-actin and spectrin, kindlin-3 maintains the erythrocyte cytoskeleton to support normal erythrocyte shape and deformability.

Keywords: leads impaired; kindlin deficiency; deficiency leads; impaired erythropoiesis; erythrocyte cytoskeleton; erythropoiesis erythrocyte

Journal Title: Blood Advances
Year Published: 2023

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