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Production and nonclinical evaluation of an autologous iPSC–derived platelet product for the iPLAT1 clinical trial

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Key Points • GMP-based iPSC-platelet production using imMKCL master cells from an aplastic anemia patient with alloimmune transfusion refractoriness.• Extensive nonclinical evaluation confirmed the safety, quality, and efficacy of the… Click to show full abstract

Key Points • GMP-based iPSC-platelet production using imMKCL master cells from an aplastic anemia patient with alloimmune transfusion refractoriness.• Extensive nonclinical evaluation confirmed the safety, quality, and efficacy of the patient iPSC-platelet product.

Keywords: nonclinical evaluation; production nonclinical; platelet product

Journal Title: Blood Advances
Year Published: 2022

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