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Association of TIM-3 checkpoint receptor expression on T cells with treatment-free remission in chronic myeloid leukemia

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Key Points • TIM-3 is the only immune-checkpoint receptor consistently overexpressed in patients with CML who relapse after TKI cessation.• Overexpression of TIM-3 provides a rationale to test TIM-3 inhibitors… Click to show full abstract

Key Points • TIM-3 is the only immune-checkpoint receptor consistently overexpressed in patients with CML who relapse after TKI cessation.• Overexpression of TIM-3 provides a rationale to test TIM-3 inhibitors to modify treatment-free remission outcomes.

Keywords: tim; checkpoint receptor; treatment free; free remission

Journal Title: Blood Advances
Year Published: 2023

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