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Treatment of congenital thrombocytopenia and decreased collagen reactivity in G6b-B–deficient mice

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Key Points • Romiplostim rescues thrombocytopenia, GPVI expression, and platelet collagen reactivity in G6b KO mice.• Intravenous immunoglobulin, Syk, and Src tyrosine kinase inhibitors have little or no benefit in… Click to show full abstract

Key Points • Romiplostim rescues thrombocytopenia, GPVI expression, and platelet collagen reactivity in G6b KO mice.• Intravenous immunoglobulin, Syk, and Src tyrosine kinase inhibitors have little or no benefit in rescuing the platelet phenotype in G6b KO mice.

Keywords: treatment congenital; collagen reactivity; reactivity g6b; mice

Journal Title: Blood Advances
Year Published: 2022

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