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Waldenström macroglobulinemia whole genome reveals prolonged germinal center activity and late copy number aberrations

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Key Points • WGS reveals that precursors with low genomic complexity have a lower risk for progression to WM.• Molecular time analysis shows chr12 gain occurred early in development, whereas… Click to show full abstract

Key Points • WGS reveals that precursors with low genomic complexity have a lower risk for progression to WM.• Molecular time analysis shows chr12 gain occurred early in development, whereas other gains occur later and may be associated with progression.

Keywords: macroglobulinemia whole; reveals prolonged; waldenstr macroglobulinemia; prolonged germinal; genome reveals; whole genome

Journal Title: Blood Advances
Year Published: 2022

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