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Clinical impact of ibrutinib plus R-CHOP in untreated DLBCL coexpressing BCL2 and MYC in the phase 3 PHOENIX trial

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Key Points • In the PHOENIX trial, the addition of ibrutinib to R-CHOP did not improve the survival of patients with previously untreated non-GCB DLBCL.• This study identified a patient… Click to show full abstract

Key Points • In the PHOENIX trial, the addition of ibrutinib to R-CHOP did not improve the survival of patients with previously untreated non-GCB DLBCL.• This study identified a patient subset with high BCL2/MYC coexpression using RNA sequencing, with improved EFS after R-CHOP with ibrutinib.

Keywords: chop; dlbcl; bcl2 myc; clinical impact; phoenix trial

Journal Title: Blood Advances
Year Published: 2023

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