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Five-year follow-up of a phase 2 study of ibrutinib plus fludarabine, cyclophosphamide, and rituximab as initial therapy in CLL

Key Points • iFCR followed by 2 years of ibrutinib maintenance led to sustained deep remission in CLL irrespective of immunoglobulin heavy-chain variable region gene status.• Recurrent CLL lacked BTK… Click to show full abstract

Key Points • iFCR followed by 2 years of ibrutinib maintenance led to sustained deep remission in CLL irrespective of immunoglobulin heavy-chain variable region gene status.• Recurrent CLL lacked BTK mutations and retained sensitivity to ibrutinib upon retreatment.

Keywords: phase study; year follow; cll; five year; follow phase; study ibrutinib

Journal Title: Blood Advances
Year Published: 2024

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