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Increased exercise tolerance in humanized G6PD-deficient mice

Key Points • G6PD-deficient mice maintain higher exercise speeds without increased red blood cell hemolysis, questioning assumed risks.• Increased cardiac output, sarcomere length, mitochondrial content, and morphology highlight adaptive benefits… Click to show full abstract

Key Points • G6PD-deficient mice maintain higher exercise speeds without increased red blood cell hemolysis, questioning assumed risks.• Increased cardiac output, sarcomere length, mitochondrial content, and morphology highlight adaptive benefits in G6PD-deficient mice.

Keywords: increased exercise; exercise tolerance; g6pd deficient; deficient mice

Journal Title: Blood Advances
Year Published: 2024

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