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Zanubrutinib is well tolerated and effective in patients with CLL/SLL intolerant of ibrutinib/acalabrutinib: updated results

Key Points • Only 40% of intolerance AEs in cohort 1 (ibrutinib intolerance) and 28% in cohort 2 (acalabrutinib intolerance) recurred with zanubrutinib.• After switching to zanubrutinib, 71% of patients… Click to show full abstract

Key Points • Only 40% of intolerance AEs in cohort 1 (ibrutinib intolerance) and 28% in cohort 2 (acalabrutinib intolerance) recurred with zanubrutinib.• After switching to zanubrutinib, 71% of patients in cohort 1 and 63% in cohort 2 maintained or had improved clinical benefit from treatment.

Keywords: tolerated effective; ibrutinib; effective patients; patients cll; well tolerated; zanubrutinib well

Journal Title: Blood Advances
Year Published: 2025

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