LAUSR

Aim: The object of study was to determine autoantibodies (Abs) in patients with rheumatoid arthritis (RA) and their correlation with clinical manifestation. Materials and Methods: 20 adults aged 60,8 ± 6,2 years old with RA, 8 patients had lung involvement and 12 age/sex matched healthy subjects were included. In all subjects were determined 24 aAb type G (dsDNA, RhF, b2GPI, LuM-membrane and LuS-cytoplasmic lung antigen (Ag), KiS-cytoplasmic and KiM-membrane kidney Ag, GaM-stomach membrane Ag, ItM-small intestine membrane Ag, HeS-liver cytoplasmic Ag, HMMP-antigen of liver mitochondria, b-adrenoreceptors, CoM-myocardial cells Ag, TrM-platelets’ Ag, ANCA, Thyroglobulin, TSH receptor, Insulin, Insulin receptors (IR), Adr-adrenal glands Ag, Membranous Ag of spermatozoids, S100, GFAP, MBP) and mean individual immune reactivity by ELISA (Immunculus, Russia). Clinical and serological markers of disease activity (CRP, ESR, RhF, anti-CCPs) were also measured. Results: The mean individual immune reactivity in RA accounted for 40% whereas it was significantly lower 8%, p Conclusions: Pulmonotropic Abs had an inverse relationship with the emergence of pulmonary manifestations in RA. This observation might support the use of these specific aAbs as early biomarkers of pulmonary parenchymatic lesions in RA.