LAUSR

The aim of this study is to investigate whether COPD exacerbations of infectious origin are different clinically and prognostically from non-infectious origin or not. We recruited 160 COPD patients between October 2015-June 2016. Patients were divided into 3 groups (group-1:patiens with pneumatic infiltration, group-2: patients don’t have pneumatic infiltration, group-3:noninfective COPD exacerbations). Obtained from the patients clinical, microbiological, radiological and functional parameters were compared. In addition, patients were prospectively monitored discharge after 3 month post discharge mortality, hospital mortality, hospitalization. The mean age:66.57±8.6 years. Sputum and purulent sputum symptoms were common in infectious exacerbations of COPD group to non-infectious exacerbation of COPD group (p=0.001).Sputum culture positivity, accompanied by pneumonia and infectious exacerbations of COPD in the group, a higher proportion of non-infectious exacerbation of COPD was seen by the group. Charlson comorbidity index, was significantly higher in the group 1 than the group 2(p=0.039).Total of 35% patients had recurrent exacerbations in 3-month follow-up period, after exacerbations treatment. However, there was no significant difference between the groups in terms of recurrence rate of patients with exacerbations. Both the mortality rate during hospitalization, as well as a total of 3 months accompanied by pneumonia and mortality rate was significantly higher than the non-infectious exacerbation of COPD group in both infectious exacerbation of COPD group. Our study showed that the patients clinical and prognostic show a different pattern according to the etiology of exacerbations of COPD