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Rhinovirus species/genotypes and interferon-λ: subtypes, receptor and polymorphisms – missing pieces of the puzzle of childhood asthma?

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We agree with Bergauer et al. [1]: in order to understand and manage asthma it is necessary to characterise better the virological and immunological factors associated with exacerbation events. In… Click to show full abstract

We agree with Bergauer et al. [1]: in order to understand and manage asthma it is necessary to characterise better the virological and immunological factors associated with exacerbation events. In their article, those authors indicated that human rhinovirus (HRV) infection may regulate type I and III interferon (IFN) expression/production in paediatric asthma, both at baseline and during disease exacerbations. Although these findings are interesting and meaningful, we are concerned about some shortcomings in their experimental design and discussion that might lead to misleading conclusions. Rhinovirus and interferon-λ: missing pieces of the puzzle of childhood asthma http://ow.ly/vBL9308zN20

Keywords: rhinovirus species; childhood asthma; missing pieces; pieces puzzle; puzzle childhood

Journal Title: European Respiratory Journal
Year Published: 2017

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