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Post hoc and pre-specified analyses of chronic obstructive pulmonary disease (COPD) randomised controlled trials have shown that higher blood eosinophil counts predict greater inhaled corticosteroid (ICS) effects on exacerbation prevention… Click to show full abstract
Post hoc and pre-specified analyses of chronic obstructive pulmonary disease (COPD) randomised controlled trials have shown that higher blood eosinophil counts predict greater inhaled corticosteroid (ICS) effects on exacerbation prevention [1–5]. COPD patients with higher blood eosinophil counts have greater eosinophil numbers in sputum, bronchoalveolar lavage and bronchial tissue, and more reticular basement membrane thickening [6]. Furthermore, increased sputum eosinophil counts are associated with reduced airway presence of pathogenic bacteria in COPD [7]. Eosinophilic COPD therefore has distinct biological features associated with increased ICS responsiveness. Blood eosinophil counts in COPD are stable over the long term http://ow.ly/aDlN30jVBCg
Journal Title: European Respiratory Journal
Year Published: 2018
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