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Nontuberculosis mycobacteria infections: would there be pharmacodynamics without pharmacokinetics?

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We appreciate the comments from H.Y. Kim and co-workers on our individual patient data meta-analysis on Mycobacterium abscessus pulmonary disease (MAB-PD) [1]. They emphasised the importance of pharmacokinetic (PK)/pharmacodynamic (PD)… Click to show full abstract

We appreciate the comments from H.Y. Kim and co-workers on our individual patient data meta-analysis on Mycobacterium abscessus pulmonary disease (MAB-PD) [1]. They emphasised the importance of pharmacokinetic (PK)/pharmacodynamic (PD) analysis and therapeutic drug monitoring (TDM) in the field of nontuberculous mycobacterial (NTM) disease, especially for MAB-PD. We generally agree with their perspective. Pharmacokinetic, pharmacodynamic and therapeutic drug monitoring data are useful in optimising treatment for Mycobacteriuam abscessus pulmonary disease, but such data are not routinely collected and analysis for clinical practice is difficult http://bit.ly/2pcTIUn

Keywords: mycobacteria infections; pharmacodynamics without; nontuberculosis mycobacteria; infections would; would pharmacodynamics; without pharmacokinetics

Journal Title: European Respiratory Journal
Year Published: 2019

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