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Low prevalence of fluoroquinolone resistance among patients with tuberculosis in the Philippines: results of a national survey

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Antimicrobial resistance (AMR) represents a global threat to public health and security. Misuse of antibiotics is the leading cause of AMR worldwide. Infections that are typically easily treatable can become… Click to show full abstract

Antimicrobial resistance (AMR) represents a global threat to public health and security. Misuse of antibiotics is the leading cause of AMR worldwide. Infections that are typically easily treatable can become life-threatening or even deadly. Multidrug-resistant (MDR) tuberculosis (TB) (defined as resistance to at least rifampicin and isoniazid, the two most powerful first-line anti-TB drugs) and extensively drug-resistant (XDR)-TB (defined as MDR-TB with additional resistance to any fluoroquinolone and a second-line injectable (SLI) agent) are forms of TB that are complex to treat, require longer and more toxic regimens [1], and have considerably worse prognosis and outcome [2, 3]. Resistance to anti-TB drugs poses a major challenge to ending the global TB epidemic by 2030 [4]. To estimate the burden of drug-resistant TB, and plan diagnostic and treatment services, surveillance of drug resistance among TB patients has been conducted worldwide since the 1990s [5]. Prevalence of fluoroquinolone resistance among Filipino TB patients is lower than in other countries in the region http://ow.ly/7ywW30ix74W

Keywords: among patients; fluoroquinolone resistance; resistance among; resistance; prevalence fluoroquinolone

Journal Title: European Respiratory Journal
Year Published: 2018

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