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Integrating haemodynamics identifies an extreme pulmonary hypertension phenotype

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Pulmonary hypertension (PH) is a highly morbid disease defined foremost by elevated mean pulmonary artery pressure (mPAP) measured during right heart catheterisation (RHC) at rest. Patients are classified further into… Click to show full abstract

Pulmonary hypertension (PH) is a highly morbid disease defined foremost by elevated mean pulmonary artery pressure (mPAP) measured during right heart catheterisation (RHC) at rest. Patients are classified further into one of three PH haemodynamic subgroups based on specific pulmonary artery wedge pressure (PAWP) and pulmonary vascular resistance (PVR) thresholds: pre-capillary PH (PAWP ≤15 mmHg+PVR ≥3.0 Wood units (WU)), isolated post-capillary PH (PAWP >15 mmHg+PVR <3.0 WU) and combined pre-/post-capillary PH (PAWP >15 mmHg+PVR ≥3.0 WU) [1]. These data illustrate the risk continuum based on multiple right heart catheterisation measurements when modelled together, but also identify pulmonary artery wedge pressure >15 mmHg and <12 mmHg as particularly high risk https://bit.ly/3whDEOV

Keywords: pulmonary hypertension; mmhg; hypertension; pulmonary artery; pvr; pawp

Journal Title: European Respiratory Journal
Year Published: 2021

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