LAUSR

Almost 30% of asthma patients exhibit reduced response to β2 and there are some side effects of this therapy. The NIV improves lung function and reduces the need for bronchodilator and has an additional important action that is the reduction of the work of breath. Meet the mechanical effects of these therapies is of great importance and can modify clinical decisions. Objective: to evaluate the effects of the NIV and the albuterol on pulmonary function and respiratory mechanics of young asthmatics after bronchial provocation (BP). Methods: a Randomized crossover trial included asthmatics aged between 12-29 years. They were evaluated by optoelectronics plethysmography (OEP) and spirometry at baseline, after BP with saline solution 4.5% and after an intervention. The order of procedures was randomized and after a week of washout this patient was attended to another treatment. NIV was set IPAP 12 and EPAP 8 for 10 min and Albuterol 400 μg. Results: were included 27 patients with an average age of 21.6 ± 4 years old (18 women). The FEV1% NIV was 107 ± 20 decrease to 78 ± 26 post BP and increased to 96 ± 22 post NIV and Albuterol 105 ± 15 to 76 ± 29 and 100 ± 14. The recovery of FEV1% after NIV was 62% and 82.7% after drug. Inspiratory capacity (IC) reduction range was 12 to 15% post BP and recovery of 105% after NIV and 125% after drug. The OEP showed a greater thoracic compartment contribution on tidal volume and the NIV returned minute volume to baseline. Conclusion: the NIV has bronchodilator effect and may recovery the IC besides to retrieve the baseline minute volume faster although the effects on lung function are more modest.