LAUSR

Background: Pulmonary arterial hypertension is a disease wlith an extremely important genetic basis. Micro RNAs (miRNAs) are non-coding RNAs that range in size 17-25 nucleotides and regulate a large variety of biological functions. The aim of our study was to look for miRNAs with potential role in the pathogenesis of PAH. Methods: Plasma samples from 25 patients with idiopathic PAH and 10 healthy controls were included. Serch and subsequent sequencing of the miRNAs were performed Results: More than 500 miRNAs were detected of wich 189 were deregulated between PAH-control groups. After filtering based on a false discovery rate of 1% and a fold change greater than 1.5, 26 miRNAs were selected. Og these, it should be noted that all of those who were under-expressed (hsa-let-7a-5p, hsa-let-7c-5p, hsa-let-7b-5p, hsa-let-7f-5p, hsa-miR-454-3p) have as one of their main tatgets the endothelin gen (EDN1) Conclusions: The expresion of miRNAs is diferent between PAH patients and general population. miRNAs related to EDN1 gene are under-expressed in PAH patients. This could lead to increased expresion on endothelin 1, a key agent in the development of PAH