LAUSR

Introduction: Treatment of pulmonary tuberculosis (TB) under identical conditions is not always effective. We’ve found out the reason of this phenomenon in the structural and functioning features of the intercellular matrix that has important substances, fibronectin and tenascin-X. Aims: Study of the effect of the rN6707530 polymorphism of the FN1 gene and the rs1150754 polymorphism of the TNXB gene on the effectiveness of chemotherapy for pulmonary TB. Methods: The research included 184 patients with pulmonary TB, which divided into 2 groups with ineffective (n=93) and effective (n=91) chemotherapy were allocated. Results: The distribution of FN1 genotypes in patients with ineffective chemotherapy was as follows: T\T – 66,7%, T\G – 30,1%, G\G – 3,2%, in patients with effective treatment was different: T\T – 3,2% (p Conclusions: Carriers of the T\T genotype rs6707530 of the FN1 polymorphism are less responsive to chemotherapy, have larger decay cavities that heal more slowly than the T\G and G\G. Polymorphism rs1150754 of the TNXB didn’t influence on the effectiveness of chemotherapy pulmonary TB.