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Autoimmune pulmonary alveolar proteinosis (aPAP) is caused by an excess of autoantibodies against granulocyte-macrophage colony-stimulating factor (GM-CSF). In this situation, the clearance of intracellular debris in alveolar macrophages is impaired,… Click to show full abstract
Autoimmune pulmonary alveolar proteinosis (aPAP) is caused by an excess of autoantibodies against granulocyte-macrophage colony-stimulating factor (GM-CSF). In this situation, the clearance of intracellular debris in alveolar macrophages is impaired, and the alveolar spaces are occupied by excessive surfactant sediments. Several serum markers (lactate dehydrogenase (LDH), KL-6, carcinoembryonic antigen and surfactant protein D), alveolar–arterial oxygen difference (PA–aO2) and the percentage diffusing capacity of the lung for carbon monoxide (%DLCO) have a correlation with the disease severity and are used to evaluate the severity of aPAP [1]. Nitric oxide and alveolar macrophage inflammation http://ow.ly/czCx30i12n8
Journal Title: ERJ Open Research
Year Published: 2018
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