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Limitations of a 6-min walk test to assess the efficacy of menthol for breathlessness

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Walking is a vital component of physical activity in patients with chronic obstructive pulmonary disease (COPD). Exertional multidimensional breathlessness in daily life can reduce walking speed and time in patients… Click to show full abstract

Walking is a vital component of physical activity in patients with chronic obstructive pulmonary disease (COPD). Exertional multidimensional breathlessness in daily life can reduce walking speed and time in patients with established COPD [1]. Improvement in breathlessness beyond a minimal clinically significant difference brought about by pulmonary rehabilitation, pharmaceutical bronchodilators and opioids has been reported [2–4]. However, despite guideline-directed disease-specific therapy, some patients with COPD experience residual breathlessness. Therefore, the application of a novel symptom-based treatment that is widely available will benefit patients with long-term breathlessness. l-Menthol is a novel treatment option for breathlessness in patients with COPD. However, the clinical application of menthol for the treatment of exertional breathlessness in these patients warrants further research. https://bit.ly/3D6rLiJ

Keywords: menthol; walk test; breathlessness; limitations min; min walk; test assess

Journal Title: ERJ Open Research
Year Published: 2022

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