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Secundum atrial septal defects (ASDs) are one of the most common congenital heart diseases and cause left-to-right shunting through the interatrial septum. The major indication for closure is a haemodynamically… Click to show full abstract
Secundum atrial septal defects (ASDs) are one of the most common congenital heart diseases and cause left-to-right shunting through the interatrial septum. The major indication for closure is a haemodynamically significant shunt, defined as a pulmonary-to-systemic flow ratio ≥1.5 with pulmonary vascular resistance <5 Wood units [1]. We investigated the diffusion mechanism in a small cohort of ASD patients before and after percutaneous closure to study the physiological impact of an ASD and its successful closure. Atrial septal defects are characterised by a low DLNO/DLCOc ratio in diffusion testing. Successful percutaneous closure shows an increase in DLNO/DLCOc ratio and vital capacity through correction of a hyperdynamic pulmonary circulation. http://ow.ly/Rqkc30o5yMM
Journal Title: ERJ Open Research
Year Published: 2019
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