LAUSR

Meta-analyses report protective effects of vitamin D supplementation against asthma exacerbations and acute respiratory infections in adults [1–3], but data relating to effects of vitamin D on risk of preschool wheeze and asthma attacks in childhood are more limited [4]. In preparation for a randomised controlled trial (RCT) of vitamin D in children with recurrent preschool wheeze or school-age asthma, we carried out a dose-escalation study to find the daily vitamin D3 supplementation regimen that is most effective in elevating circulating 25-hydroxyvitamin D (25(OH)D) concentrations in these children. We hypothesised that daily oral vitamin D3 supplementation of 1000 IU would be more effective than 400 IU (UK recommendation [5]) in elevating the circulating 25(OH)D concentration to ≥75 nmol·L−1 at 3 months in vitamin-D-insufficient children with recurrent preschool wheeze or school-age asthma. Vitamin D supplementation at the current UK recommended level (400 IU·day−1) or enhanced supplementation (1000 IU·day−1) failed to achieve adequate levels of vitamin D (>75 nmol·L−1) in vitamin-D-insufficient children with acute wheeze https://bit.ly/3J43Ouo