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Exhaled nitric oxide fraction (FENO) is a quantitative and noninvasive marker of respiratory inflammation and airway hyperresponsiveness [1]. Nitric oxide is formed by cells of the airway mucosa and via… Click to show full abstract
Exhaled nitric oxide fraction (FENO) is a quantitative and noninvasive marker of respiratory inflammation and airway hyperresponsiveness [1]. Nitric oxide is formed by cells of the airway mucosa and via the inducible nitric oxide synthase with l-arginine as a substrate [2]. Measurements of FENO can provide an indicator of type 2 airway inflammation, and might be used for diagnosis and management of diseases, especially asthma [1], although this notion was not fully supported by a recent randomised controlled trial [3]. Oral inflammation is not associated with increased FENO in nonasthmatic children and adolescents. The observed inverse association implies that gingival bleeding might decrease FENO but this needs more study to be confirmed. https://bit.ly/3IDb5nv
Journal Title: ERJ Open Research
Year Published: 2023
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