LAUSR

Background The COVID-19 pandemic has threatened the stability and adequacy of the global healthcare system. In this situation, authorities have considered engaging medical and nursing students to address the shortage of frontline healthcare workers. This study investigated the effect of COVID-19-related knowledge, attitudes, and preventive behaviors on medical and nursing students’ willingness to care for COVID-19 patients. Methods Medical and nursing students from universities in two regions of South Korea participated in this cross-sectional study. A total of 330 questionnaires were distributed; of them, 99.3% were collected, and 315 questionnaires were analyzed. Data were collected on participants’ general characteristics, COVID-19-related knowledge, attitudes, and preventive behaviors, and willingness to care for COVID-19 patients. Results In total, 66.3% of the participants were willing to care for patients during the COVID-19 pandemic. Students in higher grades and those with more clinical practice experience showed higher levels of willingness to care. Specifically, willingness to care was correlated with the senior year (OR = 3.58, 95% CI = 1.24 − 10.37, p  = .019), a high level of COVID-19-related knowledge (OR = 1.03, 95% CI = 1.00 − 1.05, p  = .041), an optimistic attitude that COVID-19 can be overcome (OR = 1.63, 95% CI = 1.24 − 2.14, p  < .001), and increased engagement in infection prevention behaviors (OR = 1.41, 95% CI = 1.16 − 1.71, p  < .001). Conclusions The findings indicated that a high level of knowledge regarding the COVID-19 pandemic, having an optimistic attitude, and engaging in preventive behaviors affected students’ willingness to care for COVID-19 patients. Integrating disaster preparedness courses in the early years of their curriculum could increase future healthcare providers’ willingness to care for patients.