Photo from academic.microsoft.com
Background Low-risk HPV infection has not been the subject of epigenetic investigation. The present study was carried out in order to investigate the methylation status of CpG sites in non-genital… Click to show full abstract
Background Low-risk HPV infection has not been the subject of epigenetic investigation. The present study was carried out in order to investigate the methylation status of CpG sites in non-genital cutaneous warts. Methods Genomic DNA was extracted from 24 paired epidermal samples of warts and normal skin. DNA samples were bisulfite converted and underwent genome-wide methylation profiling using the Infinium MethylationEPIC BeadChip Kit. Results From a total of 844,234 CpG sites, 56,960 and 43,040 CpG sites were found to be hypo- and hypermethylated, respectively, in non-genital cutaneous warts. The most differentially methylated CpG sites in warts were located within the C10orf26 , FAM83H-AS1 , ZNF644 , LINC00702 , GSAP , STAT5A , HDAC4 , NCALD , and EXOC4 genes. Conclusion Non-genital cutaneous warts exhibit a unique CpG methylation signature.
Journal Title: BMC Medical Genomics
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!