LAUSR

Dear Editor, We read with great interest the editorial written by de Waele and Sakr [1], in which the authors described their pragmatic strategy on how to search the source of a sepsis. It appears of paramount importance to precise that searching for a source of infection does not always mean finding a source of infection. Indeed, the lack of documentation (clinical or microbiological) of a source of infection during the 24 first hours of a septic shock is a common but disturbing and challenging clinical scenario reflected by the classical question “what does my patient have?” often heard during the morning rounds in many ICUs. We recently reported in the Journal the results of a pragmatic multicenter prospective observational cohort study [2] including 508 patients admitted to the ICU for a suspicion of septic shock. It is worth notifying that more than a quarter of them (n = 134/506, 26%) had no source of infection nor microbiological documentation retrieved 24 h after shock onset (defined as the start of vasopressor infusion), despite an exhaustive diagnostic work-up. Indeed, these patients underwent more diagnostic testing with more imaging procedures—including computed tomography of the chest and abdomen and echocardiography—during the first 24 h of shock management, as compared to those with a source of infection identified within the first 24 h of shock. These patients without an “early confirmed septic shock” eventually had either a source of infection or a microbiological documentation retrieved after the 24 first hours (n = 37/134, 28%)—mostly a respiratory, urinary, or abdominal sepsis—or a sepsis mimicker (n = 59/134, 44%)—mostly an adverse event of drugs, an acute mesenteric ischemia, or a malignancy—or a shock of unknown origin (n = 38/134, 28%). Mortality did not differ between patients with an early confirmed septic shock and those with a non early confirmed septic shock. Intensivists should be aware that the absence of a source of infection is not so uncommon in the first 24 h of management of a patient with a suspected septic shock. A source of infection may be diagnosed later, but the hypothesis of a sepsis mimicker should be suspected in such a context.