LAUSR

Background Sepsis-associated encephalopathy (SAE) usually manifests as sleep awakening cycle disturbance, cognitive impairment, delirium, and coma [1]. Considering that brain edema secondary to SAE is one of the complications and causes of death in patients with sepsis, early detection of intracranial hypertension (ICH) is of great significance for timely intervention and improved prognosis. However, most patients with sepsis without intracranial infection have no indications for invasive intracranial pressure (ICP) monitoring; thus, non-invasive ICP monitoring was selected. Bedside ultrasonography measurement of the optic nerve sheath diameter (ONSD) offers a favorable alternative and is presently a new technique [2, 3]. Using this method, we compared the differences in ONSD/ICP between patients with and without SAE, discussed the correlation between ONSD and Glasgow Coma Scale (GCS) score, and evaluated the value of ONSD in predicting the prognosis of patients with sepsis.