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A statistical and biological response to an informatics appraisal of healthy aging gene signatures

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Jacob and Speed did not identify even a single example of a ‘150-gene-set’ that was statistically significant at classifying Alzheimer’s disease (AD) samples, or age in independent studies. We attempt… Click to show full abstract

Jacob and Speed did not identify even a single example of a ‘150-gene-set’ that was statistically significant at classifying Alzheimer’s disease (AD) samples, or age in independent studies. We attempt to clarify the various misunderstandings, below.

Keywords: biological response; appraisal healthy; statistical biological; informatics appraisal; gene; response informatics

Journal Title: Genome Biology
Year Published: 2019

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