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BackgroundLesinurad is a novel selective uric acid salt transport protein 1 (URAT1) inhibitor which is approved in the USA for the treatment of gout. However, there are some shortcomings among… Click to show full abstract
BackgroundLesinurad is a novel selective uric acid salt transport protein 1 (URAT1) inhibitor which is approved in the USA for the treatment of gout. However, there are some shortcomings among the reported synthetic routes, such as expensive materials, environmental pollution and poor yield.ResultsIn this study, an efficient, practical and environmentally-friendly synthetic route of lesinurad is reported. The main advantages of this route include inexpensive starting materials, mild conditions and acceptable overall yield (38.8%).ConclusionGenerally, this procedure is reasonable, reliable and suitable for industrial production.Graphical abstractThe improved synthetic procedure of lesinurad (I).
Journal Title: Chemistry Central Journal
Year Published: 2017
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