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Synaptic dysfunction in complex psychiatric disorders: from genetics to mechanisms

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Editorial summaryBreakthroughs on many fronts have provided strong evidence to support synaptic dysfunction as a causal factor for neuropsychiatric diseases. Genetic studies have identified variants implicated in novel biological and… Click to show full abstract

Editorial summaryBreakthroughs on many fronts have provided strong evidence to support synaptic dysfunction as a causal factor for neuropsychiatric diseases. Genetic studies have identified variants implicated in novel biological and synaptic pathways, and animal and patient-derived induced pluripotent stem cell-based models have allowed mechanistic investigations of synaptic dysfunction in pathological processes.

Keywords: genetics; psychiatric disorders; synaptic dysfunction; complex psychiatric; dysfunction complex

Journal Title: Genome Medicine
Year Published: 2018

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