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Effective strategies to manage Burkholderia cepacia complex (Bcc) infections in cystic fibrosis (CF) patients are lacking. We tested combinations of clinically available antibiotics and show that moxifloxacin-ceftazidime could inhibit 16… Click to show full abstract
Effective strategies to manage Burkholderia cepacia complex (Bcc) infections in cystic fibrosis (CF) patients are lacking. We tested combinations of clinically available antibiotics and show that moxifloxacin-ceftazidime could inhibit 16 Bcc clinical isolates at physiologically achievable concentrations. Adding low dose of colistin improved the efficacy of the combo, especially at conditions mimicking CF respiratory secretions.
Keywords:
burkholderia cepacia;
combinations proposed;
antibiotic combinations;
cepacia complex;
novel antibiotic
Journal Title: Antimicrobial Resistance and Infection Control
Year Published: 2017
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Journal Title: Antimicrobial Resistance and Infection Control
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!