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A study of vistusertib in combination with selumetinib in patients with advanced cancers: TORCMEK phase Ib results.

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2548Background: PI3K/mTOR and MAPK pathways are aberrantly activated in many tumours and interact to promote tumour growth and therapeutic resistance. Activity of single pathway inhibition is limit... Click to show full abstract

2548Background: PI3K/mTOR and MAPK pathways are aberrantly activated in many tumours and interact to promote tumour growth and therapeutic resistance. Activity of single pathway inhibition is limit...

Keywords: study vistusertib; vistusertib combination; selumetinib patients; advanced cancers; patients advanced; combination selumetinib

Journal Title: Journal of Clinical Oncology
Year Published: 2017

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