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Genetic polymorphisms of CCL5 and CCR5 to predict efficacy of cetuximab-based treatment in metastatic colorectal cancer patients depending on primary tumor location.

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3594Background: EGFR signaling blockade increases CCL5 expression, which attracts with tumor-infiltrating leukocytes regulating either the host-derived anti-tumor immunity or tumor progression. We ... Click to show full abstract

3594Background: EGFR signaling blockade increases CCL5 expression, which attracts with tumor-infiltrating leukocytes regulating either the host-derived anti-tumor immunity or tumor progression. We ...

Keywords: genetic polymorphisms; predict efficacy; polymorphisms ccl5; ccr5 predict; ccl5 ccr5; tumor

Journal Title: Journal of Clinical Oncology
Year Published: 2017

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