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Phase I study of trametinib with neoadjuvant chemoradiation (CRT) in patients with locally advanced rectal cancers (LARC).

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3612Background: The RAS/RAF/MEK signal transduction pathway is critical to the development of colorectal cancer, and tumors harboring KRAS, NRAS, and BRAF mutations were shown to be resistant to ra... Click to show full abstract

3612Background: The RAS/RAF/MEK signal transduction pathway is critical to the development of colorectal cancer, and tumors harboring KRAS, NRAS, and BRAF mutations were shown to be resistant to ra...

Keywords: crt patients; neoadjuvant chemoradiation; study trametinib; trametinib neoadjuvant; chemoradiation crt; phase study

Journal Title: Journal of Clinical Oncology
Year Published: 2017

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