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Homologous recombination deficiency and platinum rechallenge in platinum-resistant ovarian cancer patients.

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5576Background: Ovarian carcinomas show homologous recombination deficiency (HRD) in up to 50% of cases and in 15 to 20% of cases occur due to germline BRCA1 or BRCA2 mutations. BRCA… Click to show full abstract

5576Background: Ovarian carcinomas show homologous recombination deficiency (HRD) in up to 50% of cases and in 15 to 20% of cases occur due to germline BRCA1 or BRCA2 mutations. BRCA mutated tumors...

Keywords: recombination deficiency; homologous recombination; platinum; deficiency platinum

Journal Title: Journal of Clinical Oncology
Year Published: 2017

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