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Novel resistance mechanisms to first-generation EGFR tyrosine kinase inhibitors: A perspective study in NSCLC patients using targeted next generation sequencing.

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e20576Background:Patients with non-small-cell lung cancer (NSCLC) harboring sensitive epithelial growth factor receptor (EGFR) mutations invariably develop acquired resistance to EGFR tyrosine kina... Click to show full abstract

e20576Background:Patients with non-small-cell lung cancer (NSCLC) harboring sensitive epithelial growth factor receptor (EGFR) mutations invariably develop acquired resistance to EGFR tyrosine kina...

Keywords: novel resistance; generation; resistance mechanisms; egfr tyrosine; mechanisms first

Journal Title: Journal of Clinical Oncology
Year Published: 2017

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