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Oncometabolite succinate to promote angiogenesis by upregulating VEGF expression through GPR91-mediated STAT3 and ERK activation.

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e23000Background: Altered cellular metabolism is now generally acknowledged as a hallmark of cancer cells, the resultant abnormal oncometabolites cause both metabolic and nonmetabolic dysregulation... Click to show full abstract

e23000Background: Altered cellular metabolism is now generally acknowledged as a hallmark of cancer cells, the resultant abnormal oncometabolites cause both metabolic and nonmetabolic dysregulation...

Keywords: angiogenesis upregulating; promote angiogenesis; oncometabolite succinate; succinate promote; vegf expression; upregulating vegf

Journal Title: Journal of Clinical Oncology
Year Published: 2017

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