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NAMPT inhibition is a novel synthetic lethal therapeutic approach exploiting nuclear-mitochondrial crosstalk in ERCC1-deficient populations.

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e23159Background: ERCC1 (Excision Repair Cross-Complementation group 1) deficiency is the most frequent DNA repair defect in non-small cell lung cancers (NSCLC), making this enzyme an attractive th... Click to show full abstract

e23159Background: ERCC1 (Excision Repair Cross-Complementation group 1) deficiency is the most frequent DNA repair defect in non-small cell lung cancers (NSCLC), making this enzyme an attractive th...

Keywords: novel synthetic; inhibition novel; nampt inhibition; synthetic lethal; therapeutic approach; lethal therapeutic

Journal Title: Journal of Clinical Oncology
Year Published: 2017

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