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Measuring functional HER2-driven signaling status ex vivo to predict response to HER2 therapy: Results from a mouse breast tumor xenograft study.

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e23203Background: Clinical trials indicate a weak correlation between HER2 expression levels and HER2 targeted therapy benefit. Other biological factors, such as HER2 signaling activity, may be imp... Click to show full abstract

e23203Background: Clinical trials indicate a weak correlation between HER2 expression levels and HER2 targeted therapy benefit. Other biological factors, such as HER2 signaling activity, may be imp...

Keywords: driven signaling; her2 driven; measuring functional; functional her2; therapy; her2

Journal Title: Journal of Clinical Oncology
Year Published: 2017

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