LAUSR

465Background: Aside from traditional favorable localized-nodal CUP (LNC) subsets including solitary nodal disease, women with isolated axillary adenocarcinoma and squamous cell carcinoma of cervical/inguinal lymph nodes, there is limited data on disseminated nodal CUP (DNC) presentation. Our study describes the clinicopathologic features and outcomes in nodal CUP (NCUP) highlighting the DNC subset. Methods: We performed a retrospective review of 61 NCUP patients (pts) at UTMDACC (2008 - 2015). For control group (CG), we utilized a cohort of consecutive non-NCUP pts (N = 201) from MDACC CUP database (2012 - 2013). Kaplan-Meier method was used to estimate median overall survival (mOS) and compared with log-rank tests. Results: Median age of NCUP was 61 y, similar to CG (59 y; P = 0.26). In this cohort, 19/61 (31%) and 42 (69%) were classified as LNC and DNC. DNC pts were predominantly women (65%), had good performance status (0/1: 90%), and presented with intrabdominal lymphadenopathy (79%). Sixty percent ...