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Resection margins after radical cystectomy at academic versus community cancer centers.

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315Background: Positive surgical margins are reported in 1-5% of specimens following radical cystectomy (RC) for urothelial carcinoma of the bladder (UC). Negative margin (R0) resection correlates with improved overall survival… Click to show full abstract

315Background: Positive surgical margins are reported in 1-5% of specimens following radical cystectomy (RC) for urothelial carcinoma of the bladder (UC). Negative margin (R0) resection correlates with improved overall survival (OS) following RC in individual institutional analyses compared to microscopic (R1) or grossly (R2) positive margins. The present study hypothesized that RC surgical resection margins vary between treating centers. Methods: Patients with UC undergoing RC were identified from the National Cancer Database (2004-2013). Treating centers were categorized as Academic Cancer Centers (ACC) and Community Cancer Centers (CCC). Rates of R0 vs. R1/2 resection were examined and logistic regression was performed to determine predictive factors for margin status. Results: A total of 40,187 patients were identified with a median age of presentation of 68 years. RC was performed equally at ACC (52%) compared to CCC (48%). Neoadjuvant chemotherapy was utilized more often at ACC (21%) compared to CCC...

Keywords: resection margins; community cancer; cancer; cancer centers; radical cystectomy

Journal Title: Journal of Clinical Oncology
Year Published: 2017

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