LAUSR

324Background: There is growing interest in finding inexpensive, easily reproducible biomarkers to predict outcomes in patients with urothelial bladder carcinoma (BC). An elevated preoperative neutrophil-to-lymphocyte Ratio (NLR) has been found to be an independent prognostic factor for decreased survival, predictive of upstaging at radical cystectomy (RC), and predictive of recurrence and progression. This study investigated the utility of the preoperative NLR predicting long-term outcomes in chemotherapy naive patients undergoing RC for BC at a large tertiary care center. Methods: In a retrospective cohort study, 849 RC patients with BC were identified between 2000 and 2011. NLR data for these patients was obtained within 30 days prior to RC. Univariate CART analysis was used to determine an NLR cutoff point that was significantly associated with both overall survival (OS) and disease specific survival (DSS). OS and DSS were estimated using Kaplan-Meier curves. Results: The median follow-up time among s...