LAUSR

10078Background: Childhood cancer survivors have high cumulative burden of severe and life-threatening CHC. The impact of CHC burden on self-reported HRQoL, however, has not been extensively assessed. Methods: Participants included 2666 survivors (mean age at study 34 years [range 18-66]) enrolled in the SJLIFE cohort; eligibility: survived ≥10 years and ≥18 years of age. Survivors were clinically assessed for the presence of a severe/life-threatening condition for 78 CHC using the SJLIFE modified CTCAE. HRQoL was assessed with the Short Form 36 and categorized into suboptimal ( < -0.5 SD) or optimal (≥ -0.5 SD) based on the physical and mental component summaries (PCS, MCS). A latent class analysis approach was used to generate CHC classes, identify socio-demographic and exposure determinants and estimate associations with HRQoL. Results: Unique HRQoL profiles corresponded with the three CHC latent classes identified: optimal PCS and MCS (81% of survivors), suboptimal PCS/optimal MCS (4%) and suboptimal ...