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Phase Ib study of rapid alternation of sunitinib (SU) and regorafenib (RE) in patients (pts) with advanced gastrointestinal stromal tumor (GIST).

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11510Background: Polyclonal emergence of KIT secondary mutations (muts) is the main mechanism of imatinib (IM) progression in GIST. Although approved KIT inhibitors SU and RE each suppress only a s... Click to show full abstract

11510Background: Polyclonal emergence of KIT secondary mutations (muts) is the main mechanism of imatinib (IM) progression in GIST. Although approved KIT inhibitors SU and RE each suppress only a s...

Keywords: rapid alternation; alternation sunitinib; study rapid; gist; phase study; sunitinib regorafenib

Journal Title: Journal of Clinical Oncology
Year Published: 2018

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