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A phase Ib study of ADI-PEG 20 plus pembrolizumab in advanced solid cancers.

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2556Background: Arginine deprivation with pegylated arginine deiminase (ADI-PEG 20) has been shown to upregulate tumor programmed death-ligand 1 (PD-L1) expression and T cell infiltration. Current ... Click to show full abstract

2556Background: Arginine deprivation with pegylated arginine deiminase (ADI-PEG 20) has been shown to upregulate tumor programmed death-ligand 1 (PD-L1) expression and T cell infiltration. Current ...

Keywords: peg plus; plus pembrolizumab; study adi; phase study; adi peg; pembrolizumab advanced

Journal Title: Journal of Clinical Oncology
Year Published: 2018

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