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Phase 1B study of enzalutamide (ENZA) with or without sorafenib (SORA) in patients (pts) with advanced hepatocellular carcinoma (HCC).

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4083Background: Preclinical models indicate that androgen receptor (AR) interference with ENZA is deleterious to HCC; however, ENZA also activates feedback circuitry that may be overcome with the a... Click to show full abstract

4083Background: Preclinical models indicate that androgen receptor (AR) interference with ENZA is deleterious to HCC; however, ENZA also activates feedback circuitry that may be overcome with the a...

Keywords: hcc; study enzalutamide; without sorafenib; enza without; enzalutamide enza; phase study

Journal Title: Journal of Clinical Oncology
Year Published: 2018

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