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Functional biomarkers of homologous repair (HR) deficiency to guide novel DNA damage response targeted therapy in clear cell renal cell carcinoma (ccRCC).

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4576Background: Treatment for advanced ccRCC has rapidly evolved; however, responses are not uniform and synthetic lethal treatments with associated predictive biomarkers are still lacking. We prev... Click to show full abstract

4576Background: Treatment for advanced ccRCC has rapidly evolved; however, responses are not uniform and synthetic lethal treatments with associated predictive biomarkers are still lacking. We prev...

Keywords: homologous repair; repair deficiency; biomarkers homologous; functional biomarkers; deficiency guide; cell

Journal Title: Journal of Clinical Oncology
Year Published: 2018

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