LAUSR

e13010Background: Triple negative breast cancer (TNBC) is reported as most common breast cancer subtype in Indian population with incidence nearly double of that reported in West. Optimal targeted therapeutic options for TNBC are elusive. Molecular testing for BRCA1 is difficult, mainly due to prohibitive cost and lack of wide availability. We evaluated the immunohistochemical (IHC) expression of BRCA-1 and downstream molecular targets (STAT 1 and 3) in non-familial breast cancer patients and their correlation with clinico-pathological variables Methods: 222 cases of biopsy proven sporadic breast cancer were classified based on IHC expression of ER/PR/Her-2neu/Ki-67/CK5/6. Further, IHC expression of BRCA-1, STAT1, STAT3 and pSTAT3 studied with appropriate positive and negative controls to study inter marker co-relation and correlation with clinic-pathological variables and clinical outcomes Results: TNBC was most frequent subtype (37%) followed by near equal distribution of HER2 and Luminal B (22% each) a...